CALL FOR PAPERS Physiology and GI Cancer Neonatal colonic inflammation sensitizes voltage-gated Na channels via upregulation of cystathionine -synthetase expression in rat primary sensory neurons
نویسندگان
چکیده
Ruobing Qu,* Jingde Tao,* Yongmeng Wang, Youlang Zhou, Geping Wu, Ying Xiao, Chuang-Ying Hu, Xinghong Jiang, and Guang-Yin Xu Institute of Neuroscience, Laboratory for Translational Pain Medicine, Department of Neurobiology, Soochow University, Suzhou, Peoples Republic of China; Devision of Gastroenterology, the Second Affiliated Hospital, Soochow University, Suzhou, Peoples Republic of China; Hand Surgery Research Center, Department of Hand Surgery, Affiliated Hospital of Nantong University, Nantong, Peoples Republic of China; and Department of Ear, Nose, and Throat, the Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, Peoples Republic of China
منابع مشابه
Neonatal colonic inflammation sensitizes voltage-gated Na(+) channels via upregulation of cystathionine β-synthetase expression in rat primary sensory neurons.
The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood, and treatment remains difficult. We have previously reported that colon-specific dorsal root ganglion (DRG) neurons were hyperactive in a rat model of IBS induced by neonatal colonic inflammation (NCI). This study was designed to examine plasticity of voltage-gated Na(+) channel activities and roles for the endogen...
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The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. The present study was designed to investigate roles of adrenergic signaling and the endogenous hydrogen sulfide producing enzyme cystathionine β-synthetase (CBS) in a previously validated rat model of IBS induced by neonatal colonic inflammation (NCI). Here we showed that NCI-induced...
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The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...
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The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...
متن کاملCALL FOR PAPERS Physiology and GI Cancer Neonatal maternal deprivation sensitizes voltage-gated sodium channel currents in colon-specific dorsal root ganglion neurons in rats
Hu S, Xiao Y, Zhu L, Li L, Hu C, Jiang X, Xu G. Neonatal maternal deprivation sensitizes voltage-gated sodium channel currents in colon-specific dorsal root ganglion neurons in rats. Am J Physiol Gastrointest Liver Physiol 304: G311–G321, 2013. First published November 8, 2012; doi:10.1152/ajpgi.00338.2012.—Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by ab...
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